Penicillin (carboxypenicillin)
Gram-positive: Streptococcus spp., Listeria monocytogenes
Gram-negative: Pseudomonas aeruginosa, Enterobacter, Providencia, Morganella, Proteus, H. influenzae, E. coli, Proteus mirabilis, Salmonella spp., Shigella spp.
Exerts bactericidal activity via inhibition of bacterial cell wall synthesis by binding one or more of the penicillin binding proteins (PBPs). Exerts bacterial autolytic effect by inhibition of certain PBPs related to the activation of a bacterial autolytic process.
Penicillins produce time-dependent killing
Cmax: 210mcg/ml; Half-life: 1.2mcg/ml; Table 6
Hematologic: eosinophilia, hemolytic anemia, thrombocytopenia, neutropenia
Endocrine: hypokalemia
Renal: nephrotoxicity, interstitial nephritis
Hepatic: transient increases in transaminases
Other: Jarisch-Herxheimer Reaction (fever, chills, sweating, tachycardia, hyperventilation, flushing, and myalgia)
Adult: 3g IV q4h
Pediatric: > 1 month and < 40 kg: 100-300 mg/kg/day in 4-6 divided doses
³ 40 kg: usual adult dose
Renal failure: CrCL 30-60 mL/min: 2g q4h
CrCL 10-30 mL/min: 2g q8h
CrCL < 10 mL/min: 2g q12h
Supplement after Hemodialysis: 3g
Contraindications: Anaphylaxis to ticarcillin or other penicillins
Precautions:
Live Typhoid Vaccine - decreased immunological response to the typhoid vaccine
Probenecid - increased ticarcillin levels
Category B: No evidence of risk in humans but studies inadequate.
Therapeutic: Culture and sensitivities, signs and symptoms of infection
Toxic: Periodic CBC, urinalysis, BUN, SCr, AST and ALT, diarrhea, skin rash
AERUGIPEN (Beecham - GERMANY)
TARCIL (SmithKline Beecham - AUSTRALIA)
TICAR (GlaxoSmithKline – USA, CANADA, UK)
TICARPEN (GlaxoSmithKline – FRANCE, NETHERLANDS)
TICILLIN (CSL - AUSTRALIA)
TRIACILLINE (Smith Kline Beecham - BELGIUM)