Table 3: Therapeutic Preferences and Alternatives

Vignettes

Benedek TG: Biography of Neisser

Rothschild BM.  History of Syphilis. Clin Infect Dis 2005;40:1454-1463.

Review Article: Lynn WA, Lightman S. Syphilis and HIV: a dangerous combination. Lancet Infect Dis. 2004 Jul;4(7):456-66.

Review Article:  Adhikari P, Mietzner T.  Cell Mediated Immunity. 2008.

Stoner BP. Current controversies in the management of adult syphilis. Clin Infect Dis. 2007 Apr 1;44 Suppl 3:S130-46.

Harper KN, et al.  On the origin of the trepanomatoses: a phylogenetic approach.  PLOS Neglected Tropical Diseases 2008;2:e148

Hook EW 3rd, Behets F, et al. A Phase III Equivalence Trial of Azithromycin versus Benzathine Penicillin for Treatment of Early Syphilis. J Infect Dis. 2010 Jun 1;201:1729-35.

Ghanem KG et al. Lumbar Puncture in HIV-infected Patients with Syphilis and No Neurologic Symptoms.Clin Infect Dis. 2009 Mar 15;48(6):816-210.

Hingwe, A.  Jarisch-Herxheimer reaction. 2009

Review Article:  Stamm LV.  Global Challenge of Antibiotic-Resistant Treponema pallidum.  Antimicrobial Agents and Chemotherapy 2010;54:583-589.

Authors

Lori E. Fantry, M.D., M.P.H., Edmund C. Tramont, M.D., F.A.C.P.