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Streptococcus pneumoniae
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Sliding Table of
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Tables and
Figures
Table 1: Definitions of Pneumococcal
Resistance to ß-Lactam Antibiotics
Table 2. Pneumococcal (N=1531) Resistance (%) to
Antibiotics in 33 Centers in the USA
(1999-2000).
Table 3: Representative Peak Serum Concentrations
of ß-Lactam Antibiotics in Reference to in vitro Resistance in Adults.
Table 3-a: Time Above MIC for Three Oral and Four
Parenteral β-lactam Antibiotics Tested against Penicillin-Intermediate and
Penicillin-Resistant Strains of Streptococcus pneumoniae
Table 4. Recommended Therapy for
Penicillin-Susceptible and -Resistant Pneumococcal Infections.
Table 5. Antimicrobial Therapy Recommendations for
Children and Adults with Meningitis Caused by Streptococcus pneumoniae on the
Basis of Susceptibility Tests Results
Table 6. Recommended Daily Dosages of Agents
Commonly Used for Treatment of Non-Meningeal Pneumococcal Infections.
See Table 4 For Selection Of Antibacterial Agent.
Table 7. Serum And Middle Ear Fluid Concentrations
of Antimicrobial Agents that Have Been Used for Therapy of Childhood Otitis Media and
Comparative In Vitro Activity According to Pneumococcal Susceptibility to
Penicillin.
Table 8: Antimicrobial Therapy Recommendations for Children with Acute Otitis
Media (AOM) caused by Streptococcus pneumoniae on the Basis of
Susceptibility Tests Results
Table 9: Published Reports on Mono vs. Combo in Treatment of Pneumonia (listed
in the order of time published)
Vignettes
Review
Article:
Bogaert D, De Groot R, Hermans PW. Streptococcus pneumoniae colonisation: the
key to pneumococcal disease. Lancet Infect Dis. 2004 Mar;4(3):144-54.
Review
Article: Holzman D.
Community-Acquired Pneumonia Drug Resistance Patterns Prove Puzzling. ASM
News. 2004 Nov;70(11):571-4.
Review
Article: van de Beek D, de
Gans J, McIntyre P, Prasad K. Steroids in adults with acute bacterial
meningitis: a systematic review. Lancet Infect Dis. 2004 Mar;4(3):139-43.
Review Article: Chiou CC, Yu VL.
Severe pneumococcal pneumonia: new strategies for management. Curr Opin Crit
Care Med 2006;12:470-476.
Review Article:
Efflux Pumps as a Mechanism
of Antimicrobial Resistance. 2008
Review Article:
Hsu et al. Effect of Pneumococcal Conjugate Vaccine on Pneumococcal
Meningitis. N Engl J
Med. 2009 Jan 15;360(3):244-56.
Review Article: Tebruegge M, et al.
Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial
Meningitis. Clin Microbiol Rev 2008;21:519-537.
Patient Handout: Pneumococcal Polysaccharide Vaccine
Guidelines: ACIP: Updated Recommendations for
Prevention of Invasive Pneumococcal Disease Among Adults Using the 23-Valent
Pneumococcal Polysaccharide Vaccine (PPSV23). MMWR Sept 2010.
Guchev IA, Yu VL, et al.
Management of Nonsevere Pneumonia in Military Trainees
with the Urinary Antigen Test for Streptococcus pneumoniae: An
innovative Approach to Targeted Therapy. Clin Infect Dis
2005;40:1608-16.
Gram stain,
2008.
Tsai
CJ, et al,
Changing
Epidemiology of Pneumococcal Meningitis After the Introduction of
Pneumococcal Conjugate Vaccine in the United States.
Clin Infect Dis.
2008 Jun 1;46(11):1664-72.
Jackson
LA and Janoff EN.
Pneumococcal Vaccination of Elderly Adults: New
Paradigms for Protection. Clin Infect
Dis. 2008 Nov 15;47(10):1328-38.
Johnstone
J, et al.
Impact of the pneumococcal vaccine on long-term
morbidity and mortality of adults at high risk for pneumonia.
Clin Infect Dis. 2010 Jul 1;51:15-22.
Authors
Christine C Chiou, M.D.,
David Greenberg M.D.,
 Keith P. Klugman, M.D., Ph.D.,
Charles Feldman, M.D.
First Edition (1998): Ian R. Friedland and George H. McCracken
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