In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae

Antimicrob Agents Chemother. 1996 Nov;40(11):2669-70. doi: 10.1128/AAC.40.11.2669.

Abstract

The in vitro susceptibilities of Chlamydia pneumoniae isolates to macrolide, tetracycline, and quinolone antibiotics were determined. Tetracycline, clarithromycin, and erythromycin had the lowest MICs in the first cell culture passage. Azithromycin required the lowest concentration for complete inhibition of inclusion formation on the second pass into antibiotic-free medium, likely reflecting its high intracellular concentrations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 4-Quinolones
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology
  • Azithromycin / pharmacology*
  • Chlamydophila pneumoniae / drug effects*
  • Clarithromycin / therapeutic use*
  • Microbial Sensitivity Tests
  • Tetracyclines / pharmacology

Substances

  • 4-Quinolones
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Tetracyclines
  • Azithromycin
  • Clarithromycin