Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci

Antimicrob Agents Chemother. 1995 Dec;39(12):2816-8. doi: 10.1128/AAC.39.12.2816.

Abstract

We evaluated the effects of the combination of penicillin G and gentamicin against 10 penicillin-resistant bacteremic isolates of viridans group streptococci for which the MICs of penicillin were 4 to 64 micrograms/ml. In time-kill studies, the combination resulted in more killing of eight isolates for which the MICs of penicillin were from 8 to 64 micrograms/ml than any of the antimicrobial agents tested alone. In general, clearly enhanced antimicrobial activity was observed with the combination.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / microbiology
  • Drug Synergism
  • Drug Therapy, Combination / pharmacology*
  • Gentamicins / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Penicillin G / pharmacology*
  • Penicillin Resistance*
  • Penicillins / pharmacology
  • Streptococcal Infections / microbiology
  • Streptococcus / drug effects*
  • Streptococcus sanguis / drug effects

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Penicillins
  • Penicillin G