Ceftriaxone and outpatient treatment of infective endocarditis

Infect Dis Clin North Am. 1993 Mar;7(1):97-115.

Abstract

There are a total of 8000 cases of infective endocarditis yearly in the United States. Central nervous system metastatic infections are not uncommon in infective endocarditis. Because ceftriaxone is highly bound to serum proteins, there is concern that the drug is highly bound to serum proteins, there is concern that the drug might not penetrate well in the core of an infected vegetation. To date, there are two published studies on the treatment of nonenterococcal streptococcal endocarditis by ceftriaxone in humans. Ceftriaxone appears to be an attractive alternative antibiotic therapy to conventional regimens in the treatment of streptococcal endocarditis.

Publication types

  • Review

MeSH terms

  • Ambulatory Care
  • Aneurysm, Infected / etiology
  • Animals
  • Ceftriaxone / administration & dosage
  • Ceftriaxone / pharmacology
  • Ceftriaxone / therapeutic use*
  • Costs and Cost Analysis
  • Drug Therapy, Combination / therapeutic use
  • Echocardiography
  • Embolism / etiology
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / diagnostic imaging
  • Endocarditis, Bacterial / drug therapy*
  • Heart Failure / etiology
  • Humans
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy
  • Streptococcal Infections / complications
  • Streptococcal Infections / drug therapy

Substances

  • Ceftriaxone