The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration

Eur J Clin Pharmacol. 1993;44(1):101-2. doi: 10.1007/BF00315290.

Abstract

We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 micrograms.ml-1, bronchial mucosa 1.9 micrograms.g-1, lung parenchyma 3.4 micrograms.g-, and pleural tissue 1.7 micrograms.g-1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchi / metabolism*
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / pharmacokinetics*
  • Female
  • Humans
  • Infusions, Intravenous
  • Lung / metabolism*
  • Male
  • Middle Aged
  • Mucous Membrane / metabolism
  • Pleura / metabolism*

Substances

  • Ciprofloxacin