The use of imipenem-cilastatin in neonatal meningitis caused by Citrobacter diversus

Y Haimi-Cohen; J Amir; A Weinstock; I Varsano

doi:10.1111/j.1651-2227.1993.tb12744.x

The use of imipenem-cilastatin in neonatal meningitis caused by Citrobacter diversus

Acta Paediatr. 1993 Jun-Jul;82(6-7):530-2. doi: 10.1111/j.1651-2227.1993.tb12744.x.

Authors

Y Haimi-Cohen¹, J Amir, A Weinstock, I Varsano

Affiliation

¹ Department of Pediatrics, Golda Medical Center, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tiqva, Israel.

PMID: 8338984
DOI: 10.1111/j.1651-2227.1993.tb12744.x

Abstract

Citrobacter diversus is a cause of severe meningitis in neonates and infants. It is unique in its propensity to produce brain abscesses that play an important role in the poor prognosis associated with this condition. The recommended therapeutic regimen of third-generation cephalosporines, aminoglycosides and trimethoprim-sulfamethoxazole is usually disappointing. We describe the use of imipenemcilastatin in successfully treating Citrobacter diversus meningitis complicated by brain abscesses.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Brain Abscess / complications
Brain Abscess / diagnosis
Brain Abscess / drug therapy
Cilastatin / therapeutic use*
Cilastatin, Imipenem Drug Combination
Citrobacter*
Drug Combinations
Enterobacteriaceae Infections / diagnosis
Enterobacteriaceae Infections / drug therapy*
Female
Humans
Imipenem / therapeutic use*
Infant, Newborn
Meningitis, Bacterial / complications
Meningitis, Bacterial / diagnosis
Meningitis, Bacterial / drug therapy*

Substances

Anti-Bacterial Agents
Drug Combinations
Cilastatin
Imipenem
Cilastatin, Imipenem Drug Combination