[A new therapeutic strategy using a ofloxacin-amoxicillin-clavulanic acid combination in the treatment of upper gynecologic infections. Apropos of 123 cases]

J Gynecol Obstet Biol Reprod (Paris). 1994;23(1):39-46.
[Article in French]

Abstract

Objective: To evaluate a new antibiotic strategy with a combination of ofloxacin + co-amoxiclav in the treatment of pelvic infectious diseases.

Design: An open-non-comparative multicentre (10) study.

Subjects: 123 patients (118 salpingitis and 5 endometritis) were included clinical, laparoscopic and bacteriological assessments were performed before treatment and a laparoscopic control was done in 35% of cases. Among positive bacteriological samples before treatment 48.7% C. trachomatis were isolated; 56.1% of salpingitis were considered as severe (COGIT score > 6).

Treatment: Patients received at entry oral ofloxacin 200 mg bid in combination with parenteral co-amoxiclav 2 to 4 g following by oral route. Total duration of treatment was 21 days.

Results: With respectively 97.2% and 91.6% satisfactory clinical and bacteriological results, this combination should take a major place in the treatment of pelvic infectious diseases.

Publication types

  • Clinical Trial
  • English Abstract
  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Amoxicillin / administration & dosage
  • Amoxicillin / therapeutic use*
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Bacterial Infections / drug therapy*
  • Chlamydia Infections / drug therapy
  • Chlamydia trachomatis
  • Clavulanic Acid
  • Clavulanic Acids / administration & dosage
  • Clavulanic Acids / therapeutic use*
  • Drug Therapy, Combination / therapeutic use*
  • Drug Tolerance
  • Endometritis / drug therapy
  • Endometritis / microbiology
  • Female
  • Follow-Up Studies
  • Genital Diseases, Female / drug therapy*
  • Genital Diseases, Female / microbiology*
  • Humans
  • Middle Aged
  • Ofloxacin / administration & dosage
  • Ofloxacin / therapeutic use*
  • Pelvic Inflammatory Disease / drug therapy
  • Pelvic Inflammatory Disease / microbiology
  • Remission Induction
  • Salpingitis / drug therapy
  • Salpingitis / microbiology
  • beta-Lactamase Inhibitors*
  • beta-Lactamases / administration & dosage
  • beta-Lactamases / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Clavulanic Acids
  • beta-Lactamase Inhibitors
  • Clavulanic Acid
  • Amoxicillin
  • Ofloxacin
  • beta-Lactamases