Abstract
CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Topical
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Animals
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Antiviral Agents / toxicity*
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Cottontail rabbit papillomavirus*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Female
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Organometallic Compounds / toxicity*
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Papillomavirus Infections / drug therapy*
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Papillomavirus Infections / virology
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Rabbits
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Tumor Virus Infections / drug therapy*
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Tumor Virus Infections / virology
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Warts / drug therapy*
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Warts / pathology
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Warts / virology*
Substances
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Antiviral Agents
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Organometallic Compounds
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CTC 96