Persistence of Treponema pallidum following penicillin G therapy. Report of two cases

JAMA. 1976 Nov 8;236(19):2206-7.

Abstract

The isolation of Treponema pallidum from cerebrospinal fluid (CSF) obtained from two adult patients, both of whom had normal CSF values except for positive fluorescent treponemal antibody-absorption (FTA-ABS) tests and both of whom had received currently recommended courses of penicillin, raises important considerations in the treatment of neurosyphilis in adults.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Bacterial / cerebrospinal fluid
  • Cerebrospinal Fluid / microbiology
  • Humans
  • Male
  • Middle Aged
  • Neurosyphilis / drug therapy
  • Penicillin G Benzathine / administration & dosage
  • Penicillin G Benzathine / pharmacology*
  • Penicillin G Benzathine / therapeutic use
  • Penicillin Resistance
  • Reagins / cerebrospinal fluid
  • Treponema pallidum / drug effects*
  • Treponema pallidum / isolation & purification

Substances

  • Antibodies, Bacterial
  • Reagins
  • Penicillin G Benzathine