In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria

Antimicrob Agents Chemother. 1994 Oct;38(10):2513-5. doi: 10.1128/AAC.38.10.2513.

Abstract

The in vitro activities of the N,N-dimethylglycylamido derivatives of minocycline (DMG-MINO) and 6-demethyl-6-deoxytetracycline (DMG-DMDOT) were compared with those of minocycline, tetracycline, clindamycin, and metronidazole by using the National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution method. The MICs of DMG-MINO, DMG-DMDOT, and metronidazole at which 90% of the strains were susceptible (0.5, 1, and 1 micrograms/ml, respectively) were lower than those for clindamycin, minocycline, and tetracycline (4, 8, and 32 micrograms/ml, respectively). All of the strains of anaerobes tested, except one strain of Bacteroides ovatus (MIC, 16 micrograms/ml), were susceptible to DMG-MINO and DMG-DMDOT at 8 micrograms/ml.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria, Anaerobic / drug effects*
  • Clindamycin / pharmacology
  • Metronidazole / pharmacology
  • Minocycline / analogs & derivatives*
  • Minocycline / pharmacology
  • Tetracyclines / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Tetracyclines
  • Metronidazole
  • 9-(N,N-dimethylglycylamido)minocycline
  • 6-demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline
  • Clindamycin
  • Minocycline