The in vitro studies revealed a number of promising drugs including gentamicin, doxycycline and minocycline for the treatment of malleus. The malleus causative agent was found to be highly susceptible to sulfamonomethoxine and biseptol as well as to imipenem and ofloxacin. Cephalosporins were less active but in the therapeutic concentrations they inhibited the growth of Pseudomonas mallei. In the treatment of golden hamsters infected subcutaneously by P. mallei ofloxacin proved to be the most active drug, then followed biseptol, doxycycline and minocycline. None of the tested drugs cured the animals infected aerogenically by 160 LD50 of P. malleus. When the infective dose was lower (16 LD50) only doxycycline provided a 70-percent protection of the animals.