Results at 5 years of a controlled comparison of a 6-month and a standard 18-month regimen of chemotherapy for pulmonary tuberculosis

Am Rev Respir Dis. 1977 Jul;116(1):3-8. doi: 10.1164/arrd.1977.116.1.3.

Abstract

The relapse rate up to 5 years after the start of chemotherapy with a 6-month regimen of daily streptomycin, isoniazid, and rifampin has been compared with the rate for a standard 18-month regimen of streptomycin, thiacetazone, and isoniazid for 2 months, followed by thiacetazone and isoniazid for 16 months daily. There were 5 bacteriologic relapses in 145 patients on the 6-month regimen, 1 occurring between 3 and 5 years after admission compared with 3 in 125 patients on the 18-month regimen, 1 occurring between 3 and 5 years.

Publication types

  • Comparative Study

MeSH terms

  • Drug Therapy, Combination
  • Humans
  • Isoniazid / therapeutic use
  • Patient Dropouts
  • Recurrence
  • Rifampin / therapeutic use
  • Streptomycin / therapeutic use
  • Thioacetazone / therapeutic use
  • Time Factors
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / mortality

Substances

  • Thioacetazone
  • Isoniazid
  • Rifampin
  • Streptomycin