In vitro activities of trimethoprim and sulfamethoxazole against Listeria monocytogenes

Antimicrob Agents Chemother. 1982 Jul;22(1):51-4. doi: 10.1128/AAC.22.1.51.

Abstract

The in vitro activities of trimethoprim and sulfamethoxyazole against clinical isolates of Listeria monocytogenes were examined separately and in combination with a microtiter broth dilution system. Sulfamethoxazole demonstrated variable activity and was generally bacteriostatic. Trimethoprim alone was bactericidal against 96% of isolates at less than 0.5 microgram/ml. The bactericidal action of trimethoprim against L. monocytogenes was generally potentiated by sulfamethoxyazole even when isolates were relatively resistant to sulfamethoxyazole alone.

MeSH terms

  • Humans
  • Listeria monocytogenes / drug effects*
  • Listeriosis / microbiology
  • Microbial Sensitivity Tests
  • Sulfamethoxazole / pharmacology*
  • Time Factors
  • Trimethoprim / pharmacology*

Substances

  • Trimethoprim
  • Sulfamethoxazole