Single and multiple verrucous plantaris lesions are well known for their resistance to conservative methods of treatment. In an effort to destroy verrucous growth, the authors have attempted to alter the genetic structure of these obstinate, benign warty lesions by using the antibiotic, bleomycin sulfate. This study provides a review of the medical literature and presents the intralesional injection technique of 0.1% bleomycin into the wart tissue itself. The impressive and significant success rate for complete resolution of verrucous lesions without subsequent scarring has shown this approach to be an effective treatment for plantar warts.