Oral amoxycillin, an alternative treatment for neurosyphilis

Genitourin Med. 1985 Dec;61(6):359-62. doi: 10.1136/sti.61.6.359.

Abstract

A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus 500 mg probenecid twice a day attained treponemicidal CSF amoxycillin concentrations. Thus amoxycillin by mouth offers an effective alternative method for treating patients with neurosyphilis.

MeSH terms

  • Administration, Oral
  • Amoxicillin / administration & dosage*
  • Amoxicillin / cerebrospinal fluid
  • Amoxicillin / therapeutic use
  • Animals
  • Disease Models, Animal
  • Female
  • Humans
  • Male
  • Neurosyphilis / drug therapy*
  • Probenecid / therapeutic use
  • Rabbits
  • Treponema pallidum / drug effects

Substances

  • Amoxicillin
  • Probenecid