The penetration of ofloxacin into lung tissue

J Antimicrob Chemother. 1988 Sep:22 Suppl C:85-9. doi: 10.1093/jac/22.supplement_c.85.

Abstract

After a single oral 600 mg dose, ofloxacin concentrations were measured in lung tissue, whole blood and plasma in 11 patients undergoing thoracotomy for a bronchial malignancy. To correct for blood contamination in the tissue samples, the tissue haemoglobin content was measured using a method based on the binding of haemoglobin by haptoglobin. Ofloxacin concentrations in plasma and whole blood did not differ significantly. The calculated blood content in the tissue samples was 0.12 +/- 0.05 ml/g lung tissue. After correction for blood admixture, the mean lung tissue concentration 2 h after administration of ofloxacin was 17.7 +/- 9.2 micrograms/g. At the same time the mean plasma concentration was 8.7 +/- 4.2 mg/l (P less than 0.02). The high concentration of ofloxacin obtained in lung tissue does not result from the preparation technique. After a single 600 mg dose the tissue concentrations proved to exceed MIC values for most pathogens frequently involved in respiratory tract infections.

MeSH terms

  • Aged
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Lung / metabolism*
  • Male
  • Middle Aged
  • Ofloxacin / blood
  • Ofloxacin / pharmacokinetics*

Substances

  • Ofloxacin