Abstract
PD 127,391, a newly developed 4-quinolone chemically similar to ciprofloxacin, was studied in vitro by using agar and broth dilution and two inoculum sizes. PD 127,391 was found to be highly active against gram-negative aerobes, including Pseudomonas aeruginosa and other Pseudomonas spp. Its activity against gram-positive aerobes was better than that of ciprofloxacin.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Bacteria, Aerobic / drug effects*
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Ceftazidime / pharmacology
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Chemical Phenomena
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Chemistry
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Ciprofloxacin / pharmacology
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Fluoroquinolones*
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Gentamicins / pharmacology
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Gram-Negative Aerobic Bacteria / drug effects
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Humans
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Imipenem / pharmacology
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Gentamicins
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Ciprofloxacin
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Imipenem
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clinafloxacin
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Ceftazidime