Klebsiella bacteremia. A 10-year review in a cancer institution

Cancer. 1989 Dec 1;64(11):2368-76. doi: 10.1002/1097-0142(19891201)64:11<2368::aid-cncr2820641129>3.0.co;2-h.

Abstract

A total of 368 episodes of Klebsiella bacteremia occurred in 330 cancer patients, representing a rate of four episodes per 1000 hospital admissions. Eighty-eight percent of these infections were acquired nosocomically and 58% of the patients received antibiotics during the preceding 10-day period. There was pulmonary infection in 24% of the patients, shock in 25%, and disseminated intravascular coagulation in 7%. The overall response rate was 69%. Response rates were significantly lower among patients with shock (25% versus 83%), hemorrhage (29% versus 76%), and pneumonia (37% versus 79%). The combination of a cephalosporin plus an aminoglycoside produced the highest response rate (79%). Klebsiella sp continue to be an important cause of infection in patients with cancer.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Cancer Care Facilities*
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Cross Infection / drug therapy
  • Cross Infection / epidemiology*
  • Female
  • Fever
  • Hospitals, Special*
  • Humans
  • Infant
  • Klebsiella Infections / complications
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / mortality
  • Length of Stay
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sepsis / drug therapy
  • Sepsis / epidemiology*
  • Superinfection / epidemiology

Substances

  • Anti-Bacterial Agents