Treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin

R J Dworkin; B L Lee; M A Sande; H F Chambers

doi:10.1016/s0140-6736(89)91083-0

Treatment of right-sided Staphylococcus aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin

Lancet. 1989 Nov 4;2(8671):1071-3. doi: 10.1016/s0140-6736(89)91083-0.

Authors

R J Dworkin¹, B L Lee, M A Sande, H F Chambers

Affiliation

¹ Department of Medicine, University of California, San Francisco.

PMID: 2572799
DOI: 10.1016/s0140-6736(89)91083-0

Abstract

A combination of ciprofloxacin (intravenous then oral) and oral rifampicin was tested in 14 intravenous drug users with right-sided Staphylococcus aureus endocarditis. All 10 patients who completed therapy were cured based on resolution of symptoms and negative blood cultures at 4 weeks post therapy.

MeSH terms

Adult
Ciprofloxacin / administration & dosage
Ciprofloxacin / therapeutic use*
Drug Administration Schedule
Drug Therapy, Combination
Echocardiography
Endocarditis, Bacterial / drug therapy*
Endocarditis, Bacterial / etiology
Endocarditis, Bacterial / microbiology
Female
Follow-Up Studies
Humans
Male
Pilot Projects
Rifampin / administration & dosage
Rifampin / therapeutic use*
Staphylococcal Infections / drug therapy*
Staphylococcal Infections / etiology
Staphylococcal Infections / microbiology
Substance Abuse, Intravenous / complications*

Substances

Ciprofloxacin
Rifampin