A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

M E Patarroyo; R Amador; P Clavijo; A Moreno; F Guzman; P Romero; R Tascon; A Franco; L A Murillo; G Ponton

doi:10.1038/332158a0

A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria

Nature. 1988 Mar 10;332(6160):158-61. doi: 10.1038/332158a0.

Authors

M E Patarroyo¹, R Amador, P Clavijo, A Moreno, F Guzman, P Romero, R Tascon, A Franco, L A Murillo, G Ponton, et al.

Affiliation

¹ Instituto de Inmunologia, Hospital San Juan de Dios, Universidad Nacional de Colombia, Bogota, SA.

PMID: 2450281
DOI: 10.1038/332158a0

Abstract

We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus triviroatus monkeys experimentally infected with P. falciparum. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Amino Acid Sequence
Animals
Antibodies, Protozoan / analysis
Antigens*
Antigens, Protozoan / immunology
Chromatography, High Pressure Liquid
Enzyme-Linked Immunosorbent Assay
Epitopes / immunology
Fluorescent Antibody Technique
Humans
Immunity, Cellular
Malaria / immunology
Malaria / prevention & control*
Male
Peptides / analysis
Peptides / immunology
Plasmodium falciparum / immunology*
Vaccines*
Vaccines, Synthetic*

Substances

Antibodies, Protozoan
Antigens
Antigens, Protozoan
Epitopes
Peptides
Vaccines
Vaccines, Synthetic