Abstract
The novel β-lactamase gene bla(CTX-M-116) was identified in a Proteus mirabilis nosocomial isolate recovered from the urine of a patient in Moscow in 2005. DNA sequence analysis showed bla(CTX-M-116) to be a hybrid gene consisting of 5' bla(CTX-M-23) (nucleotides 1 to 278) and 3' bla(CTX-M-22) (nucleotides 286 to 876) moieties separated by an intervening putative site of recombination (GTTAAAT). A retrospective analysis of available bla(CTX-M) genes in the GenBank database revealed 19 bla(CTX-M) genes that display the same hybrid structure.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cross Infection / drug therapy
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Cross Infection / microbiology
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Databases, Nucleic Acid
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli Proteins / genetics*
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Humans
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Molecular Sequence Data
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Protein Isoforms / genetics
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Proteus Infections / drug therapy
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Proteus Infections / microbiology
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Proteus mirabilis / drug effects
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Proteus mirabilis / enzymology
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Proteus mirabilis / genetics*
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Proteus mirabilis / isolation & purification*
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Recombination, Genetic
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Sequence Homology, Nucleic Acid
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
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beta-Lactams / therapeutic use
Substances
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Escherichia coli Proteins
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Protein Isoforms
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beta-Lactams
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beta-Lactamases
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beta-lactamase CTX-M-22, E coli
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beta-lactamase CTX-M-23, E coli