Treponema pallidum azithromycin resistance in Dublin, Ireland

Sex Transm Dis. 2012 Oct;39(10):784-6. doi: 10.1097/OLQ.0b013e318269995f.

Abstract

This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics*
  • Female
  • Humans
  • Ireland / epidemiology
  • Male
  • Middle Aged
  • Mutation*
  • RNA, Ribosomal, 23S / genetics
  • Syphilis / drug therapy*
  • Syphilis / epidemiology
  • Treponema pallidum / drug effects*
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • RNA, Ribosomal, 23S
  • Azithromycin