Abstract
This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology*
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Azithromycin / pharmacology*
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial / drug effects
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Drug Resistance, Bacterial / genetics*
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Female
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Humans
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Ireland / epidemiology
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Male
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Middle Aged
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Mutation*
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RNA, Ribosomal, 23S / genetics
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Syphilis / drug therapy*
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Syphilis / epidemiology
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Treponema pallidum / drug effects*
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Young Adult
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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RNA, Ribosomal, 23S
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Azithromycin