In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species

Antimicrob Agents Chemother. 2012 Apr;56(4):2194-7. doi: 10.1128/AAC.06274-11. Epub 2012 Jan 30.

Abstract

TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria, Anaerobic / drug effects*
  • Bacterial Infections / microbiology
  • Cephalosporins / pharmacology*
  • Colony Count, Microbial
  • Corynebacterium / drug effects*
  • Culture Media
  • Daptomycin / pharmacology
  • Glycopeptides / pharmacology*
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Culture Media
  • Glycopeptides
  • TD 1792
  • Vancomycin
  • Daptomycin