Abstract
TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacteria, Anaerobic / drug effects*
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Bacterial Infections / microbiology
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Cephalosporins / pharmacology*
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Colony Count, Microbial
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Corynebacterium / drug effects*
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Culture Media
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Daptomycin / pharmacology
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Glycopeptides / pharmacology*
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Gram-Positive Bacteria / drug effects
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Humans
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Microbial Sensitivity Tests
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Culture Media
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Glycopeptides
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TD 1792
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Vancomycin
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Daptomycin