Abstract
We report our experience with a 9-month-old infant treated with intravenous polymyxin B for multidrug-resistant Klebsiella pneumoniae bacteremia. Serial blood samples were obtained at steady state and serum drug concentrations were determined using a validated liquid chromatography-mass spectrometry method. The elimination half-lives of polymyxin B1 and isoleucine-polymyxin B1 were found to be 3.1 and 4.7 hours, respectively.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacokinetics*
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Bacteremia / drug therapy*
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Bacteremia / microbiology
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Chromatography, Liquid
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Drug Resistance, Multiple, Bacterial*
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Female
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Half-Life
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Humans
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Infant
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Infusions, Intravenous
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Klebsiella Infections / drug therapy*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / isolation & purification
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Mass Spectrometry
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Polymyxin B / administration & dosage
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Polymyxin B / pharmacokinetics*
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Serum / chemistry
Substances
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Anti-Bacterial Agents
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Polymyxin B