Abstract
Three patients admitted to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes. In two of these cases, the patients were initially infected by carbapenem-susceptible S. marcescens isolates. Molecular typing and plasmid analysis suggested that all three patients had clonally indistinguishable isolates of S. marcescens that acquired a plasmid-mediated bla(KPC-2) gene during the hospitalization.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Bacterial Proteins / genetics*
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Carbapenems / pharmacology
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Carbapenems / therapeutic use
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Electrophoresis, Gel, Pulsed-Field
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Female
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Greece
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Plasmids / genetics*
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Pneumonia, Bacterial / drug therapy
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Pneumonia, Bacterial / microbiology
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Serratia Infections / drug therapy
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Serratia Infections / microbiology*
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Serratia marcescens* / drug effects
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Serratia marcescens* / genetics
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Serratia marcescens* / isolation & purification
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-lactamase KPC-2
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beta-Lactamases