Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan

P P A M van Thiel; T Leenstra; P A Kager; H J de Vries; M van Vugt; W F van der Meide; A Bart; J E Zeegelaar; A van der Sluis; H D F H Schallig; T van Gool; W R Faber; P J de Vries

doi:10.1086/648726

Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan

Clin Infect Dis. 2010 Jan 1;50(1):80-3. doi: 10.1086/648726.

Authors

P P A M van Thiel¹, T Leenstra, P A Kager, H J de Vries, M van Vugt, W F van der Meide, A Bart, J E Zeegelaar, A van der Sluis, H D F H Schallig, T van Gool, W R Faber, P J de Vries

Affiliation

¹ Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. p.p.vanthiel@amc.nl

PMID: 19951107
DOI: 10.1086/648726

Abstract

In a retrospective, observational study involving 34 patients with Leishmania major infection, 31 of whom had experienced unsuccessful treatment with intralesional antimony (ilSb(v)), miltefosine proved effective. Thirty patients experienced cure after receipt of miltefosine, 3 after receipt of additional ilSb(v), and 1 after 28 daily intravenous injections of antimony. Temporary diminution of ejaculate volume was reported by 21 patients.

MeSH terms

Adult
Afghanistan
Female
Humans
Leishmania major / isolation & purification*
Leishmaniasis, Cutaneous / diagnosis
Leishmaniasis, Cutaneous / drug therapy*
Male
Middle Aged
Military Personnel
Netherlands
Phosphorylcholine / adverse effects
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / therapeutic use
Retrospective Studies
Travel
Treatment Outcome

Substances

Phosphorylcholine
miltefosine