Side-effects of quinolones: comparisons between quinolones and other antibiotics

Eur J Clin Microbiol Infect Dis. 1991 Apr;10(4):378-83. doi: 10.1007/BF01967014.

Abstract

Fluoroquinolones are generally very safe antibiotics which do not cause serious or life-threatening adverse reactions. The most frequent side-effects are gastrointestinal reactions (nausea, dyspepsia, vomiting) and CNS reactions such as dizziness, insomnia and headache. Many of the more severe CNS reactions seem to be due to metabolic interaction with theophylline, especially when enoxacin is used. Of the potentially serious side-effects, photoxicity has been reported in varying frequencies with the different fluoroquinolones. Caution is necessary when this group of drugs, especially pefloxacin, is prescribed to patients who will have intensive exposure to UV light during treatment. The finding in juvenile animals of cartilage damage after administration of high doses have resulted in recommendations that fluoroquinolones should not be used in children. Carefully monitored studies should be performed in paediatric patients to assess whether there is a real risk of such adverse reactions.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • 4-Quinolones
  • Animals
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / toxicity
  • Anti-Infective Agents / adverse effects*
  • Anti-Infective Agents / toxicity
  • Bone and Bones / drug effects
  • Cartilage / drug effects
  • Central Nervous System / drug effects*
  • Child
  • Child, Preschool
  • Digestive System / drug effects*
  • Drug Interactions
  • Eye / drug effects
  • Humans
  • Joints / drug effects
  • Photosensitivity Disorders / chemically induced

Substances

  • 4-Quinolones
  • Anti-Bacterial Agents
  • Anti-Infective Agents