Activity of daptomycin against Listeria monocytogenes isolates from cerebrospinal fluid

Antimicrob Agents Chemother. 2008 May;52(5):1850-1. doi: 10.1128/AAC.01139-07. Epub 2008 Feb 19.

Abstract

We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to 8.0 and the MIC at which 90% of the isolates tested were inhibited (MIC(90)) was 4.0 mg/liter. For the Etest method, the MIC range was 1.0 to 4.0 and the MIC(90) was 4.0 mg/liter. Presently, daptomycin cannot be recommended for the treatment of L. monocytogenes meningitis.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Daptomycin / pharmacology*
  • Humans
  • Listeria monocytogenes / drug effects*
  • Listeria monocytogenes / isolation & purification
  • Listeriosis / cerebrospinal fluid*
  • Listeriosis / microbiology
  • Microbial Sensitivity Tests
  • Netherlands

Substances

  • Anti-Bacterial Agents
  • Daptomycin