Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent

Dae-Hwan Suk; Dominik Rejman; Christine C Dykstra; Radek Pohl; Krzysztof W Pankiewicz; Steven E Patterson

doi:10.1016/j.bmcl.2007.02.063

Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent

Bioorg Med Chem Lett. 2007 May 15;17(10):2811-6. doi: 10.1016/j.bmcl.2007.02.063. Epub 2007 Feb 25.

Authors

Dae-Hwan Suk¹, Dominik Rejman, Christine C Dykstra, Radek Pohl, Krzysztof W Pankiewicz, Steven E Patterson

Affiliation

¹ Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.

PMID: 17360182
DOI: 10.1016/j.bmcl.2007.02.063

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

MeSH terms

Animals
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / pharmacology*
Drug Design*
Giardia / drug effects*
Humans
Molecular Structure
Nucleotides / chemistry
Nucleotides / pharmacology*
Organophosphonates / chemistry
Organophosphonates / pharmacology*
Structure-Activity Relationship

Substances

Antiprotozoal Agents
Nucleotides
Organophosphonates