Abstract
A large outbreak of infection and colonization with multiple genera of gram-negative bacilli carrying the metallo- beta -lactamase gene bla(IMP-4) occurred in a 36-bed intensive care unit at a tertiary hospital in Australia. The organisms emerged rapidly, caused severe infections, and contributed to mortality. Controlling the spread of these organisms remains a challenge for all staff involved.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Australia / epidemiology
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Cross Infection / epidemiology*
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Cross Infection / microbiology
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Disease Outbreaks*
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Female
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / enzymology*
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Gram-Negative Bacteria / genetics
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Gram-Negative Bacteria / growth & development*
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Gram-Negative Bacterial Infections / epidemiology*
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Intensive Care Units*
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Male
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Middle Aged
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / isolation & purification
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Serratia marcescens / drug effects
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Serratia marcescens / enzymology
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Serratia marcescens / isolation & purification
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beta-Lactam Resistance
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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beta-lactamase IMP-4
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beta-Lactamases