Association between the replication capacity and mother-to-child transmission of HIV-1, in antiretroviral drug-naive Malawian women

J Infect Dis. 2006 Jun 1;193(11):1512-5. doi: 10.1086/503810. Epub 2006 Apr 20.

Abstract

Replication capacity and transmission of human immunodeficiency virus (HIV)-1 in antiretroviral drug-naive Malawian women who had subtype C infection were investigated. Infant children of these women received either 1 dose of nevirapine or 1 dose of nevirapine plus 1 week of daily doses of zidovudine. PhenoSense HIV was used to determine replication capacity in 49 women whose infants were infected with HIV-1 and in 47 women whose infants were uninfected by 6-8 weeks of age. Mean replication capacity was higher in transmitters than in nontransmitters (P=.01). In a multivariate model, higher replication capacity was associated with transmission (odds ratio, 1.45 for each 10% increase in replication capacity [95% confidence interval, 1.11-1.90]; P = .0063), after adjustment for maternal HIV-1 load and other factors.

MeSH terms

  • Adult
  • Cell Line
  • Female
  • Genes, Reporter
  • HIV Infections / transmission*
  • HIV Infections / virology*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • HIV-1 / physiology*
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical*
  • Luciferases / analysis
  • Luciferases / genetics
  • Malawi
  • Mothers
  • Multivariate Analysis
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Statistics as Topic
  • Virus Replication*

Substances

  • Luciferases