Thorough examination of the lower anogenital epithelium of promiscuous men and their partners (either male or female) may be useful to diagnose and, if appropriate, treat those who are likely to perpetuate the HPV epidemics and increase the potential risk for cervical carcinogenesis. CO2 laser ablation is a highly attractive means to treat HPV-related disease of the anogenital epithelium in men. The Nd:YAG laser also has some specific applications in the treatment of large, relatively vascular lesions. A stable sexual relationship or consistent use of condoms in polygamous sexual practices is probably the most meaningful means of controlling the sexual transmission of HPV.