Abstract
Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-resistance among established 5-nitromidazole antiparasitic drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / pharmacology*
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Drug Resistance
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Giardia lamblia / drug effects*
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Metronidazole / pharmacology*
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Molecular Weight
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Nitroimidazoles / pharmacology*
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Structure-Activity Relationship
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Trichomonas vaginalis / drug effects*
Substances
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Antiprotozoal Agents
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Nitroimidazoles
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Metronidazole