Syntheses and antiulcer activities of 2-aminonorbornene derivatives

Chem Pharm Bull (Tokyo). 1992 Jan;40(1):102-8. doi: 10.1248/cpb.40.102.

Abstract

2,2,-Disubstituted norbornenes (1, 2), 2,2-Disubstituted norbornane (3), 2,2,3-trisubstituted norbornenes (4, 5), oxanorbornenes (6) and azanorbornenes (7) were synthesized by the Diels-Alder reaction using alpha, beta-dehydroamino acids as a key step, and their antiulcer activities were examined. The oxazolidine derivative (1h) exhibited the most potent activities against several ulcer-models in rat.

MeSH terms

  • Animals
  • Anti-Ulcer Agents / chemical synthesis*
  • Anti-Ulcer Agents / pharmacology
  • Male
  • Norbornanes / chemical synthesis*
  • Norbornanes / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / etiology
  • Stomach Ulcer / prevention & control
  • Stress, Psychological

Substances

  • Anti-Ulcer Agents
  • Norbornanes
  • 2-aminonorbornene