Abstract
Agar and broth microdilution MICs of Ro 23-9424 that inhibited 90% of 22 Legionella clinical isolates tested were 0.64 and 0.08 micrograms/ml, respectively; respective erythromycin values were 1.0 and 0.12 micrograms/ml. Ro 23-9424 (1 microgram/ml) was slightly more active than the same erythromycin concentration in a macrophage system, for both Legionella pneumophila strains studied.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / pharmacology*
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Cefotaxime / analogs & derivatives*
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Cefotaxime / pharmacology
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Colony Count, Microbial
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Culture Media
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Erythromycin / pharmacology
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Extracellular Space / microbiology
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Fleroxacin / analogs & derivatives*
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Fleroxacin / pharmacology
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Fluoroquinolones*
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Guinea Pigs
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Intracellular Fluid / microbiology
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Legionella / drug effects*
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Macrophages, Alveolar / microbiology
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Microbial Sensitivity Tests / methods
Substances
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Anti-Infective Agents
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Culture Media
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Fluoroquinolones
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Ro-23-9424
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Erythromycin
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Cefotaxime
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Fleroxacin