In vitro activity of Ro 23-9424 against clinical isolates of Legionella species

Antimicrob Agents Chemother. 1992 Nov;36(11):2559-61. doi: 10.1128/AAC.36.11.2559.

Abstract

Agar and broth microdilution MICs of Ro 23-9424 that inhibited 90% of 22 Legionella clinical isolates tested were 0.64 and 0.08 micrograms/ml, respectively; respective erythromycin values were 1.0 and 0.12 micrograms/ml. Ro 23-9424 (1 microgram/ml) was slightly more active than the same erythromycin concentration in a macrophage system, for both Legionella pneumophila strains studied.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology*
  • Cefotaxime / analogs & derivatives*
  • Cefotaxime / pharmacology
  • Colony Count, Microbial
  • Culture Media
  • Erythromycin / pharmacology
  • Extracellular Space / microbiology
  • Fleroxacin / analogs & derivatives*
  • Fleroxacin / pharmacology
  • Fluoroquinolones*
  • Guinea Pigs
  • Intracellular Fluid / microbiology
  • Legionella / drug effects*
  • Macrophages, Alveolar / microbiology
  • Microbial Sensitivity Tests / methods

Substances

  • Anti-Infective Agents
  • Culture Media
  • Fluoroquinolones
  • Ro-23-9424
  • Erythromycin
  • Cefotaxime
  • Fleroxacin