Abstract
We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus (VISA) that did not respond to high doses of vancomycin. Initial vancomycin MIC of the last isolate recovered from blood was 8 micro g/mL, but could be induced up to 32 micro g/mL by consecutive growing with vancomycin. Clinical response was only accomplished when linezolid was included in therapy.
MeSH terms
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Drug Resistance, Multiple, Bacterial
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Endocarditis / drug therapy
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Endocarditis / microbiology*
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Female
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Humans
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Microbial Sensitivity Tests
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Middle Aged
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Oxacillin / pharmacology
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / classification
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / isolation & purification*
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Vancomycin / pharmacology
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Vancomycin / therapeutic use
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Vancomycin Resistance*