Abstract
The successful treatment of a 7-month-old infant with shunt-associated ventriculitis caused by vancomycin-resistant Enterococcus faecium is presented. Linezolid was administered intravenously every 8 h; children have a greater volume of distribution and total body clearance than adults and therefore require more frequent dosing. The patient tolerated the therapy without adverse effects.
MeSH terms
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Acetamides / therapeutic use*
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Anti-Bacterial Agents / therapeutic use
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Encephalitis / drug therapy*
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Encephalitis / microbiology*
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Enterococcus faecium / isolation & purification*
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology*
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Humans
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Hydrocephalus / drug therapy
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Hydrocephalus / microbiology
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Infant
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Linezolid
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Male
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Oxazolidinones / therapeutic use*
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Vancomycin Resistance*
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Ventriculoperitoneal Shunt / adverse effects
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid