Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae

Sue E Baum; Sharon A Crawford; M L McElmeel; Cynthia G Whitney; James H Jorgensen

doi:10.1128/AAC.46.9.3094-3095.2002

Comparative activities of the oxazolidinone AZD2563 and linezolid against selected recent North American isolates of Streptococcus pneumoniae

Antimicrob Agents Chemother. 2002 Sep;46(9):3094-5. doi: 10.1128/AAC.46.9.3094-3095.2002.

Authors

Sue E Baum¹, Sharon A Crawford, M L McElmeel, Cynthia G Whitney, James H Jorgensen

Affiliation

¹ Infectious Disease Service of Brooke Army Medical Center, San Antonio, Texas, USA.

Abstract

The activity of AZD2563 against 250 highly resistant pneumococci and 267 drug-susceptible isolates was determined. The AZD2563 MICs for 50 and 90% of the strains tested were 1 and 2 micro g/ml and 0.5 and 1 micro g/ml, respectively, for the two isolate groups. These MICs were within 1 log(2) dilution of those of linezolid.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acetamides / pharmacology*
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Microbial
Humans
Linezolid
Microbial Sensitivity Tests
North America
Oxazolidinones / pharmacology*
Pneumococcal Infections / microbiology
Streptococcus pneumoniae / drug effects*

Substances

Acetamides
Anti-Bacterial Agents
Oxazolidinones
posizolid
Linezolid