Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis

Antimicrob Agents Chemother. 2002 Jun;46(6):2004-6. doi: 10.1128/AAC.46.6.2004-2006.2002.

Abstract

Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 microg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a bla(OXA-23) probe showed that the gene was chromosome encoded in the P. mirabilis strain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Chromosomes, Bacterial / genetics*
  • Kinetics
  • Microbial Sensitivity Tests
  • Nucleic Acid Hybridization
  • Proteus mirabilis / drug effects
  • Proteus mirabilis / enzymology*
  • Proteus mirabilis / genetics*
  • beta-Lactamases / genetics*
  • beta-Lactams

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-lactamase OXA-23
  • beta-Lactamases