In vitro activity of ABT-773 versus macrolides and quinolones against resistant respiratory tract pathogens

Diagn Microbiol Infect Dis. 2001 May-Jun;40(1-2):35-40. doi: 10.1016/s0732-8893(01)00249-8.

Abstract

ABT-773, a novel ketolide, was compared to erythromycin, azithromycin, clarithromycin, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, gatifloxacin, and gemifloxacin against antibiotic-resistant strains recently isolated from patients with respiratory tract infections. MICs were determined by agar dilution using standard NCCLS methodology. ABT-773 (MIC(90) 0.06 mg/L) was more active than the macrolides (MIC(90) > or = 2 mg/L) and fluoroquinolones (MIC(90) > or = 0.5 mg/L) against penicillin-resistant Streptococcus pneumoniae. The fluoroquinolones were the most active agents tested against beta-lactamase-positive Haemophilus influenzae (MIC(90) < or = 0.01-0.06 mg/L), against which ABT-773 (MIC(90) 4 mg/L) was comparable to azithromycin and two- and four-fold more active than erythromycin and clarithromycin, respectively. Against beta-lactamase positive Moraxella catarrhalis, the activity of ABT-773 (MIC(90) 0.06 mg/L) was comparable to gemifloxacin, trovafloxacin, levofloxacin, and ciprofloxacin (MIC(90) 0.03-0.06 mg/L) and 4- to eightfold greater than that of clarithromycin, gatifloxacin, and erythromycin. These data suggest ABT-773 could be a valuable compound for the treatment of respiratory tract infections, including those resistant to usual oral therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacterial Infections / microbiology
  • Drug Resistance, Microbial
  • Erythromycin / analogs & derivatives*
  • Erythromycin / pharmacology*
  • Fluoroquinolones
  • Haemophilus influenzae / drug effects
  • Humans
  • Ketolides*
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects
  • Respiratory Tract Infections / microbiology*
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pyogenes / drug effects

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Fluoroquinolones
  • Ketolides
  • Erythromycin
  • cethromycin