Abstract
We evaluated the efficacy of an ointment containing bacitracin, polymyxin B, and gramicidin for the eradication of colonization by methicillin-resistant Staphylococcus aureus in 11 medical patients, 10 (91%) of whom had previously failed a 1-week course of topical mupirocin. Mupirocin resistance was documented in 5 (45%) of 11 patients. Successful decolonization was achieved in 9 (82%) of 11 patients (based on 2 months of follow-up).
MeSH terms
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Aged
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Aged, 80 and over
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Anti-Infective Agents, Local / pharmacology*
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Bacitracin / pharmacology*
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Drug Combinations
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Drug Therapy, Combination / pharmacology*
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Female
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Gramicidin / pharmacology*
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Humans
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Male
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Methicillin Resistance*
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Middle Aged
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Mupirocin / pharmacology
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Ointments
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Pilot Projects
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Polymyxin B / pharmacology*
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Staphylococcus aureus* / drug effects*
Substances
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Anti-Infective Agents, Local
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Drug Combinations
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Ointments
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polysporin ointment
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Bacitracin
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Gramicidin
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Mupirocin
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Polymyxin B