Haemophilus influenzae type B disease, vaccines, and care of exposed individuals

J Fam Pract. 2000 Sep;49(9 Suppl):S7-13; quiz S14.

Abstract

Before effective vaccines became available, approximately 1 in every 200 children aged younger than 5 years had invasive Haemophilus influenzae type b (Hib) disease. Hib was the most common cause of bacterial meningitis and other invasive bacterial diseases in this age group. Rapid diagnosis and treatment are essential for Hib meningitis, because the mortality rate is 2% to 5%, even with antibiotic treatment--usually a third-generation cephalosporin, such as cefotaxime or ceftriaxone. Because of the use of Hib vaccines, the incidence of invasive H. influenzae disease in children younger than 5 years old declined by 97% between 1987 and 1997. Recent data indicate that the conjugate Hib vaccines given in infancy can be used interchangeably.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Child, Preschool
  • Contraindications
  • Haemophilus Infections / diagnosis
  • Haemophilus Infections / epidemiology
  • Haemophilus Infections / prevention & control*
  • Haemophilus Vaccines* / administration & dosage
  • Haemophilus influenzae type b / immunology*
  • Humans
  • Immunization Schedule
  • Infant
  • Meningitis, Haemophilus / prevention & control
  • United States / epidemiology

Substances

  • Haemophilus Vaccines