In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs

Antimicrob Agents Chemother. 2000 Sep;44(9):2567-8. doi: 10.1128/AAC.44.9.2567-2568.2000.

Abstract

Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg/ml), although ofloxacin also showed good activity, with an MIC(90) of 2 microg/ml. Trovafloxacin and gemifloxacin showed lower in vitro activity, with MIC(90)s of 64 and 8 microg/ml, respectively.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Drug Resistance, Microbial / physiology
  • Fluoroquinolones
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / isolation & purification

Substances

  • Anti-Infective Agents
  • Antitubercular Agents
  • Fluoroquinolones