Abstract
Logistic regression analysis was performed on data drawn from a clinical trials database for Staphylococcus aureus septicaemia treated with teicoplanin. Variables analysed were age, body weight, mean pre-dose and post-dose serum teicoplanin concentrations, mean dose (mg or mg/kg body weight) and combination versus monotherapy. Only two variables correlated with clinical outcome at a significance level better than 0.05: age (P = 0.012) and mean pre-dose serum concentration (P = 0.010). The probability of successful treatment declined with age and increased with mean pre-dose serum concentration.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Algorithms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / therapeutic use*
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Body Weight
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Humans
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Logistic Models
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Microbial Sensitivity Tests
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Middle Aged
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Sepsis / drug therapy*
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Sepsis / epidemiology
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / epidemiology
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Teicoplanin / administration & dosage
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Teicoplanin / blood
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Teicoplanin / therapeutic use*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Teicoplanin