Comparison of the effects of continuous and intermittent systemic administration on the penetration of gentamicin into infected rabbit eyes

J Infect Dis. 1983 Jan;147(1):144-8. doi: 10.1093/infdis/147.1.144.

Abstract

The effect of the mode of administration on the intraocular penetration of gentamicin in rabbits with bacterial endophthalmitis was examined. Animals were treated over a period of 12 hr either by intramuscular injection every 3 hr or by continuous intravenous infusion; both groups received the same total dose of drug. The mean peak and trough levels in serum with intramuscular injection were 11.4 and 1.6 micrograms/ml, respectively. Mean serum levels during continuous infusion were approximately 7 micrograms/ml. The area under the time-concentration curve for serum was approximately the same in both groups. Mean vitreous humor levels at the end of therapy were 2.8 micrograms/ml in the animals treated by repeated intramuscular injection and 2.6 micrograms/ml in those treated by continuous infusion (P greater than 0.2). In this model, the intraocular penetration of gentamicin was not influenced by the mode of systemic administration.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cornea / analysis
  • Drug Administration Schedule*
  • Eye Diseases / drug therapy*
  • Gentamicins / administration & dosage
  • Gentamicins / therapeutic use*
  • Rabbits
  • Staphylococcal Infections / drug therapy*
  • Tissue Distribution
  • Vitreous Body / analysis

Substances

  • Gentamicins