Comparison of single-dose administration and three-day course of amoxicillin with those of clavulanic acid for treatment of uncomplicated urinary tract infection in women

Antimicrob Agents Chemother. 1991 Aug;35(8):1688-90. doi: 10.1128/AAC.35.8.1688.

Abstract

In a double-blind randomized study we compared a single-dose amoxicillin-clavulanate combination with a regular 3-day regimen in 109 women with cystitis. Clinical cure rates at 7 and 28 days posttreatment were 78 versus 87% and 67 versus 78%, respectively. The 3-day regimen was significantly better (P less than 0.001) only in women with recurrent urinary tract infections.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amoxicillin / therapeutic use*
  • Anti-Bacterial Agents / therapeutic use*
  • Clavulanic Acid
  • Clavulanic Acids / therapeutic use*
  • Cystitis / drug therapy
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Middle Aged
  • Urinary Tract Infections / drug therapy*

Substances

  • Anti-Bacterial Agents
  • Clavulanic Acids
  • Clavulanic Acid
  • Amoxicillin