|
Dose
(mg/kg) |
Route |
Subjects
(n)* |
Cmax
(µg/l) |
tmax
(h) |
t½
(h) |
ka
(1/h) |
V/F
(l/kg) |
CL/F
(l/h/kg) |
Ref. |
|
3.6
(single) |
i.m. |
2;
H |
- |
- |
23.1 |
1.1 |
28.5 |
0.86 |
59
|
|
3.2
day 1, then 1.6 daily for 4 d |
i.m. |
2;
H |
- |
- |
69.3 |
0.4 |
23.8 |
0.24 |
59
|
* H = healthy adult volunteers, Cmax=maximum plasma concentration; tmax=time of maximum concentration; t1/2=elimination half-life; ka=first order absorption rate constant; V/F= volume of distribution after non-i.v. administration; CL/F=clearance after non-i.v. administration.