Table 1.  Case Types of E. Corrodens Infections

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Central nervous system

brain abscess, meningitis, subdural empyema.

 

Head and neck

Eye, ear and nose:  dacryocystitis, lacrimal abscess, conjunctivitis, orbital cellulitis, keratitis, otitis, nasal abscess.

Oral cavity:  alveolar abscess, submandibular gland abscess, parotitis, peritonsillar abscess.

Upper and lower jaws, sinuses: chronic diffusing sclerosing osteomyelitis

of the mandible, maxillary osteitis, maxillary sinusitis, frontal sinusitis, cervicofacial actinomycosis.

Others: thyroiditis, thyroid abscess, bronchial arch cyst infections, mastoid osteitis, facial abscess, forehead cellulitis, facial wounds.

 

Chest

Pneumonia, empyema, pulmonary abscess, chest wall wounds, mediastinitis.

 

Abdominal cavity

Subdiaphragmatic abscess, pancreatic abscess, spleen abscess, abdominal abscess, appendicitis, sacral abscess, appendiceal abscess, esophagus empyema, pelvic abscess, retroperitoneal abscess, liver abscess, intraperitoneal abscess, abdominal wounds.

 

Cardiovascular system

Bacteremia/septicemia, endocarditis, vascular prosthesis infections.

 

Extremities

Bite wounds, paronychia, skin abscess, foot amputation stump, ankle arthritis, osteomyelitis.

 

Genitourinary and reproductive systems

Cervicitis, Bartholin's abscess, perirectal abscess, inguinal abscess, chorioamnionitis.

 


Table 2.  Comparative Activity of Antimicrobial Agents Against E. Corrodens*

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Antibiotics                                MIC50 (mg/ml)            MIC90 (mg/ml)            Range (mg/ml)

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Beta-lactams

            Penicillin G                    1.25                             2.5                               0.6-5

Ampicillin                  0.5                               1                                  0.5-4

Amoxicillin                0.5                               0.5                               0.125-0.5

clavulanate

Faropenem                0.25                             0.25                             0.125-0.25      

Ertapenem                 0.03                             0.03                             0.03

Imipenem                   0.12                             0.25                             0.12-0.25

            Meropenem                  0.03                             0.03                             <0.013-0.03   

            Moxalactam                  0.03                             0.25                             0.3-1

            Cefotaxime                    0.06                             0.5                               0.016-1

            Cefoxitin                        0.5                               0.5                               0.25-1

            Mezlocillin                    0.12                             1                                  0.06-32

            Ticarcillin                      1                                  2                                  0.25-4

            Loracarbef                    4                                  4                                  0.015-8

            Cefoperazone               0.5                               4                                  0.25-32

            Bacampicillin                2                                  4                                  2-8

            Piperacillin                    0.25                             4                                  0.06-32

            Cefprozil                        8                                  8                                  0.06-8

            Cephaloridine               16                                16                                8-32

            Cephapirin                     8                                  16                                8-16

            Cefazolin                       8                                  16                                4-32

            Cephalothin                  16                                32                                8-32

            Cephalexin                     >64                             >64                              0.125->64

            Cefaclor                         8                                  32                                4-32

            Cefamandole                 16                                64                                8-64

            Cephradine                   64                                64                                32-128

            Cefadroxil                      >64                              >64                              0.25->64

            Methicillin                     >16                              >16                              8->16

            Dicloxacillin                   >128                            >128                            64->128

Quinolones

            DU-6859a                       0.002                           0.004                           0.001-0.008

             Moxifloxacin                 0.016                           0.06                             0.008-0.125

[Bay 12-8039]

            Ciprofloxacin                  0.015                           0.015                           0.008-0.06

            Garenoxacin                    0.06                             0.125                           <0.002-0.25

            [BMS-284756]

Gatifloxacin                 0.016                           0.016                           0.008-0.125

Gemifloxacin                0.06                             0.06                             0.03-0.06

Levofloxacin                0.015                           0.015                           0.015-0.03

            Ofloxacin                          0.015                           0.03                             0.008-0.125

            Sparfloxacin                     0.015                           0.03                             0.008-0.03

            Trovafloxacin                  0.06                             0.06                             0.008-0.25

            Ofloxacin                          0.03                             0.03                             0.015-0.125

            Amifloxacin                      0.003                           0.06                             0.15-1

            Norflorxacin                     0.03                             0.06                             0.15-0.5

            Difloxacin                         0.06                             0.125                           0.008-0.5

            Enoxacin                           0.06                             0.125                           0.03-2

            Trovofloxacin                  0.06                             0.06                             0.008-0.25

            Nalidixic acid                   1                                  2                                  0.25-16

            Cinoxacin                         2                                  2                                  0.5-16

Tetracyclines

            Tetracycline                     0.5                               2.0                               0.5-2.0

            Doxycycline                     1                                  2                                  0.25-4

            Minocycline                     0.25                             1                                  0.125-1

            GAR-936                           0.5                               4                                  0.25-4

Macrolides

            Erythromycin                   2                                  4                                  0.06-4

            Azithromycin                   1                                  2                                  0.06-4

            Roxithromycin                 32                                32                                4->32

            Clarithromycin                 2                                  4                                  0.125-4

Ketolides

            RU-64004                          0.25                             0.5                               0.03-1.0

            Telithromycin                  0.5                               1                                  0.03-1.0

            [HMR3647]

            ABT-773                           1                                  1                                  0.125-2

Lincosamides

            Clindamycin                     32                                64                                16->128

            Lincomycin                      >100                            >100                            >100

Oxazolidinones

Linezolid                       8                                  16                                4-16    

Glycopeptides

            Vancomycin                     32                                64                                4-64

            Teicoplanin                      32                                32                                8-32

Aminoglycosides

            Streptomycin                   8                                  16                                8->16

            Gentamicin                       4                                  4                                  4-8

Nitroimidazoles

            Metronidazole                 >100                            >100                            >100

Trimethoprim-sulfamethoxazole 0.125                           0.25                             0.06-0.5

Chloramphenicol                         2                                  4                                  1->16

Rifampin                                       2                                  4                                  1-8

Synercid                                       8                                  16                                0.06-16

[Quinpristin/dalfopristin]

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*Data based on various published reports.